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Natural Anxiety Supplements for a Regulated Nervous System
If you are dealing with anxiety, you are not alone – it is the most common mental health challenge of our modern day. In the U.S., over 40 million adults are affected by anxiety disorders (National Institute of Mental Health, 2023). In Canada, about 3 million adults (11.6% of the population) have been diagnosed with a mood and/or anxiety disorder (Government of Canada, 2023). Of those, 81.8% report using medication and/or counseling for treatment, with 47.6% using prescription medication alone (Government of Canada, 2017). While pharmaceuticals have their place, they often come with harsh side effects, long-term dependencies, and don’t always address the deeper causes of anxiety.
Natural remedies offer another path—one rooted in ancient wisdom and backed by modern science. From psilocybin’s neuroplasticity-boosting effects to the calming properties of ashwagandha and passionflower, these plant-based allies can help you cultivate a sense of calm, clarity, and resilience. Whether you’re looking for subtle daily support or a deeper shift, nature provides powerful tools to help you find your calm.
Keep reading for:
Psilocybin, the active compound in magic mushrooms, is being researched and shows exciting promise for its potential effects on mood and well-being. Once ingested, it converts into psilocin, which interacts with serotonin receptors, helping to reset the brain’s neural networks. By modulating the default mode network, which is often responsible for anxious thoughts and rumination, psilocybin can shift rigid thinking patterns and open the door to new perspectives.
It also suppresses amygdala activity, reducing fear-based emotional responses and allowing deep processing of difficult memories. Combined with its ability to increase neuroplasticity, psilocybin helps solidify healthier thought patterns, emotional responses, and habits.
High-dose, guided psilocybin journeys have shown profound and lasting improvements in anxiety. Here’s how it works:
Dip your toe in with our Lite Brite Microdosing Capsules, which contain 125 mg of Golden Teacher magic mushrooms alongside other calming plants and adaptogenic herbs to soothe anxiety and uplift mood. Or, take a dive deeper with our Magic Mushroom Chocolate Bars, which can be customized to the dose you’re looking for – whether microdose or macrodose.
Only undertake a full journey under the supervision of an experienced facilitator, trusted trip sitter, or psychedelic therapist and read our Guide to Macrodosing for more info on the preparation, journey, and post-ceremony integration.
Consult our Magic Mushroom Dosing Guide for help finding your ideal dose and protocol.
Ashwagandha is an adaptogenic herb used in Ayurvedic medicine to help the body adapt to stress. By balancing cortisol levels—the stress hormone—it supports a calm, centered state and reduces anxiety. Research shows that ashwagandha can improve overall mental health by enhancing sleep quality and cognitive function.
CBD, a non-psychoactive compound from the cannabis plant, interacts with the endocannabinoid system to help regulate mood and stress. Research suggests it can help ease anxiety, promote relaxation, improve sleep by lowering nighttime cortisol levels, and lessen tension-related headaches and muscle tightness—all without the mind-altering effects of THC.
Passionflower is a natural sedative that is used in herbal medicine to treat anxiety and insomnia. It is believed to increase levels of GABA in the brain, which helps reduce overactivity, promote relaxation, and support restful sleep.
You can find passionflower, CBD, and ashwagandha in our Lite Brite Microdosing Capsules, our bestselling magic mushroom microdose blend designed to quell anxiety, lift mood, and improve sleep.
Valerian root has been used for centuries to ease anxiety and improve sleep. Like passionflower, it’s believed to increase GABA levels, calming the nervous system and reducing stress. Research suggests it can help relieve restlessness, anxious thoughts, and irritability while promoting deep, restorative sleep.
L-theanine, an amino acid found in green tea, promotes relaxation without drowsiness by increasing alpha-wave activity, a brain state linked to calm focus and mental clarity. It helps regulate neurotransmitters, reducing stress while enhancing concentration and cognitive function. Research suggests it can be an effective natural aid for easing anxiety and supporting emotional stability.
L-Theanine is naturally abundant in matcha, the star ingredient in our Matcha Star Bar, crafted to support relaxation, balance, and calm focus.
Vitamin D3 is essential for mood regulation, brain health, and emotional resilience. Low levels have been linked to increased anxiety, making it important to get enough. Sunlight is the most powerful source, but if exposure is limited, a supplement can help restore balance. Before adding any vitamin supplement to your life, consult a healthcare professional to check your levels first.
Read our blog, Circadian Rhythm: How to Adjust it Naturally, for more on the power of sunlight exposure and other natural, zero-cost methods to improve sleep, modulate mood, and quell anxiety.
Omega-3 fatty acids, found in fish oil and certain plant-based foods, are essential for brain health and have powerful anti-inflammatory effects. Studies show that omega-3s can reduce anxiety and improve mood regulation. Here’s how they help:
Magnesium is an essential mineral involved in over 300 biochemical reactions in the body, including nervous system regulation and muscle function. Low levels have been linked to heightened anxiety, restless sleep, and tension in both body and mind. Ensuring adequate magnesium intake can help:
Though it’s not a supplement, regular movement is one of the most effective natural remedies for anxiety. Whether it’s weight lifting, running, yoga, or dancing, regular exercise has been shown to:
Lite Brite, our bestselling microdose blend combines nature’s most powerful anxiety-reducing, calm-inducing plant medicines and adaptogens—thoughtfully handcrafted to bring more balance, calm, and clarity to your mind and spirit. Each capsule is an invitation to deepen your connection with yourself, supported by the wisdom of the earth. Inside you’ll find:
“If you are on the fence – get on the other side of it because I promise you this is the answer you’ve searched for ! I’m 50 year old female who has been diagnosed with Generalized Anxiety Disorder since the age of 24, on and off meds my entire life, after one microdose (125 mg) I felt better after one hour than I have in years of taking antidepressants. It’s like someone turned off the “crazy switch” – I’m focused, calm, present, mindful, creative. I feel like this little capsule has saved my life.” – Nicole
It all depends on your approach. Our Lite Brite Microdosing Capsules are formulated for subtle daily support that helps mood metrics rise gradually over time alongside intentional effort. High-dose psilocybin like that found in our Magic Mushroom Chocolate, however, can have much faster and more powerful results. Research has shown that a single dose of high-level psilocybin can significantly decrease or eliminate depression and anxiety, with about 80% of study participants sustaining these changes six months later. Keep in mind though, these transformative effects aren’t just about the dose—proper guidance, a supportive setting, and intentional integration are essential to ensure lasting, meaningful change.
In comparison, prescription antidepressants can take weeks to months to take effect and have about a 30-40% success rate on reducing anxiety symptoms. Other, more immediate anti-anxiety drugs like benzodiazepines that are only designed to be used occasionally can start treating anxiety symptoms within an hour but wear off within 2-24 hours.
“Lite Brite microdosing has been the answer to my anxiety and struggle with ADHD along with improved overall wellness. I am a 40 year old female and choose this, effectively, over antidepressants. I have tried other blends, from Sero and other brands. Sero, Lite Brite particularly, is the best I have found. I started with a lower dose and found 250 mg to be my sweet spot. On days where I need more of boost to feel happy (not tripping) I take 500 mg. I generally do 5 days on, 2 off. Taking 750 mg to 1.5 grams to feel a high or trip is better than most gummies I have tried. The Lite Brite blend is just perfect. Thank you Sero!” – Gina
While herbal supplements can be powerful allies in your healing journey, it’s important to be aware of any contraindications, especially if you’re already on prescription medication. Here’s a few to watch out for:
Always consult a mental health professional before incorporating new herbal supplements into your routine, especially if you’re taking medication. For more detailed contraindication information, refer to:
While supplements are a powerful support to help guide you to a better state, true healing is a journey that begins from within. It involves embracing and tending to the many layers of your human experience—reprogramming the mind, reconnecting with the body, and reclaiming your emotional balance. Supplements are just one tool on this path, but it is the inner work that leads to lasting transformation.
Try this two step reprogramming ritual to return to the body and get to the root of anxious thoughts:
As you question your thoughts, the stories (and the corresponding anxiety) will begin to unravel. After doing this practice for a while, your anxious thoughts begin to lose their power over you and feelings of anxiety decrease. In the end, you begin to realize that you’re in control – not your thoughts.
These simple yet impactful rituals can help regulate the nervous system, shift anxious thought patterns, release stored tension, and cultivate a deep sense of resilience from within. And remember, even small shifts can have a profound impact:
Psilocybin, ashwagandha, passionflower, and magnesium are some of the most effective natural supplements for anxiety.
Name three things you see, three things you hear, and move three parts of your body. This simple grounding technique takes your attention out of your mind and into the present moment.
A holistic approach can include natural supplements, a nutrient-rich diet, movement, sunlight exposure, quality sleep, and most importantly – identifying and reprogramming your anxious thoughts.
Deficiencies in Vitamin D3, magnesium, and omega-3s have been linked to increased anxiety symptoms.
Ashwagandha and passionflower are among the strongest herbal remedies for reducing anxiety symptoms.
True anxiety relief goes beyond masking symptoms—it’s about becoming conscious of your thoughts and emotions, and intentionally creating a life you love. Our Lite Brite Microdosing Capsules are designed for subtle daily support, helping to ease anxiety and uplift mood over time alongside your own intentional efforts. For a deeper, more transformative shift, our Magic Mushroom Chocolate Bars offer customizable doses for profound emotional and mental shifts. Whether you’re looking for steady support or an intensive breakthrough, we’re here to support you on your journey.
National Institute of Mental Health. (2023). Any Anxiety Disorder. Retrieved from https://www.nimh.nih.gov/health/statistics/any-anxiety-disorder
Government of Canada. (2023). Mood and Anxiety Disorders in Canada. Retrieved from https://www.canada.ca/en/public-health/services/publications/diseases-conditions/mood-anxiety-disorders-canada.html
Government of Canada. (2017). Use of Medication and Psychological Counselling Among Canadians with Mood and Anxiety Disorders. Retrieved from https://www.canada.ca/en/public-health/services/reports-publications/health-promotion-chronic-disease-prevention-canada-research-policy-practice/vol-37-no-5-2017/use-medication-psychological-counselling-canadians-with-mood-anxiety-disorders.html
