What Is the Stamets Stack by Paul Stamets & Our Connect Four Microdose Formula

What Is the Stamets Stack by Paul Stamets & Our Connect Four Microdose Formula

Developed by Paul Stamets, the Stamets Stack pairs psilocybin (the active ingredient in magic mushrooms) with lion’s mane and niacin (vitamin B3) for a powerful, brain-boosting microdose formula.
connect four stamets stack microdosing capsules

If you’re a seasoned psychonaut, you’ve likely heard of the Stamets Stack. If you’re new, allow us to introduce you to this brain-enhancing, mood-improving, soul-connecting blend. 

In today’s blog, we’re diving deep into the Stamets Stack, an incredible microdosing protocol for brain health, increased focus and memory, and overall wellness. Keep reading for: 

      • What is microdosing and stacking 
      • What is the Stamets Stack and who is Paul Stamets? 
      • The Stamets Stack inspired blend at Sero: Connect Four
      • Breaking down the ingredients in the Stamets Stack: the benefits and purpose of psilocybin mushrooms, lion’s mane, and niacin
      • The Stamets Stack Protocol
      • Community reviews of Connect Four, our Stamets Stack inspired formula

First, what is microdosing and stacking?

Before we get into the Stamets Stack, let’s go over some basics like the meaning of microdosing – this involves taking a small, sub-perceptual dose of a psychedelic substance like psilocybin with the goal of improving well-being. ‘Stacking’ is the practice of combining multiple healing compounds for increased and targeted benefits.

While microdosing alone is incredibly powerful, it works best when paired with clear intentions and ongoing reflection. Psilocybin helps you access higher states of consciousness to know yourself more clearly and discover the areas you can grow, evolve, and heal. Once you’re aware of the patterns, thoughts, and behaviours you want to address, microdosing further supports your growth by increasing neuroplasticity (your brain’s ability to change and adapt following learning or experience).

Who is Paul Stamets?

A world-renowned Mycologist, author, researcher and speaker, Paul Stamets is the leading expert in all things mushrooms and fungi. Having received over 20 mushroom-related patents and countless scientific awards, he aligns science with the spiritual and shares the healing potential of mushrooms with people around the world.

What is the Stamets Stack?

Developed by Paul Stamets, the Stamets Stack pairs psilocybin (the active ingredient in magic mushrooms) with lion’s mane and niacin (vitamin B3) for a powerful, brain-boosting microdose formula.

connect four stamets stack mushroom blend

The ingredients in the Stamets Stack explained

What is psilocybin?

A naturally occurring psychedelic compound produced by over 200 strains of mushrooms. Psilocybin mushrooms, which the body converts into psilocin, increases neuroplasticity and promotes the growth of new neural connections in the brain.

Psilocybin mushrooms have shown promise in treating depression, anxiety, migraines and cluster headaches, OCD, Alzheimer’s, and many forms of substance abuse.

At Sero, we focus on Golden Teacher mushrooms, a strain of psilocybin mushroom from the species Psilocybe cubensis known for its thought-provoking and uplifting spiritual experiences.

What is lion’s mane?

Also known as the hedgehog mushroom, lion’s mane is a medicinal mushroom known its nerve regenerative and nerve protective abilities. 

What does lion’s mane do for the brain and body? 

A seriously satiating brain food, lion’s brain stimulates the brain to produce, grow, and maintain vital neurons.

In one lion’s mane study, researchers introduced a neurotoxin into the brains of mice, which created dementia-like symptoms of impaired memory, confusion, etc. They then treated the mice with lion’s mane mushrooms and the symptoms disappeared. 

Another study confirmed lion’s mane’s ability to promote neurogenesis and enhance memory through neural growth. Researchers believe it could be used in the treatment and prevention of neurodegenerative disorders like Alzheimer’s. 

benefits of lion's mane
The full-body benefits of lion’s mane: 

Brain: improves memory, focus, and concentration. Stimulates the production of nerve growth factors which protect existing neurons, produce new neurons, and maintain healthy neurons. 

Gut: supports a healthy gut by improving gut bacteria balance and reducing inflammation. 

Immune: boosts the immune system with reduced inflammation and antioxidants. Helps reverse cellular damage. 

Mood: improves mood, decreases anxiety, and boosts energy levels. 

Insulin: helps improve insulin sensitivity

What is niacin?

Niacin (Vitamin B3) is a B vitamin created in the body and found naturally in many foods. Alongside the other B vitamins, niacin helps the body convert food into energy.

B vitamins are essential for healthy skin, hair, eyes, liver, and nervous system health. Niacin also helps the body make many hormones, reduces inflammation, and improves circulation. 

Niacin is also involved in serotonin production and some studies have found it can help boost brain function and improve symptoms of anxiety and depression.

Why is niacin in the Stamets Stack?

Niacin works as a flushing agent and causes the blood vessels to expand – this means it can help transport other molecules (like lion’s mane and Psilocybin) across the blood-brain barrier to more effectively reach the brain and nervous system. Niacin basically chauffeurs the brain-boosting molecules straight to the cells to begin their healing. 

So, how do all the ingredients in the Stamets Stack work together?

Lion’s mane is rich in erinacines and hericenones, compounds shown to improve cognitive function and stimulate growth of new brain cells. Alongside psilocybin’s ability to increase neuroplasticity and promote the growth of new neural connections in the brain, that’s a pretty powerful brain boosting elixir. Niacin then acts as the transport vehicle to take these two ingredients deeper into the cells. 

When taken as a trio, many users have experienced improved memory, focus and overall cognitive function, increased creativity, and improvements in anxiety and depression.

The Stamets Stack at Sero

With the incredible amount of anecdotal success using the Stamets Stack plus the widespread struggle to find correct doses and quality sources of each of these three compounds, we decided to create an all-in-one formula with the optimum doses of each compound already built in. 

connect four stamets stack microdosing capsules

Meet: Connect Four, our microdose formulation inspired by the Stamets Stack. Created to enhance cognitive function and promote neurogenesis, it’s formulated with optimized amounts of golden teacher magic mushrooms, lion’s mane, and niacin for the brain-boosting elixir touted and proven by Paul Stamets and many users around the world.

Connect Four is beloved among our community for its healing effects with anxiety, depression, MS, concussion symptoms, grief, plus overall improvements in mood and well-being. Scroll down to read a few of our customer’s stories or visit the Connect Four page to read them all

Our Connect Four blend + all our products are made with ethically harvested, high-quality magic mushrooms and sustainably sourced, locally grown ingredients. Every batch is tested for quality and consistency.

The Stamets Dosing Protocol

Paul Stamets recommends a dosing schedule of 5 days on, 2 days off for four weeks. He then recommends a break of two to four weeks to avoid building a tolerance in the body.

For more on microdosing protocols and tips, visit our blog, Microdosing 101.

What our community says about Connect Four – our Stamets Stack Inspired Formula

“I have ADHD so I ordered Connect four to be more focused. And It’s given me focus and a sense of calm. I couldn't replace my ADHD medication with Connect four, but for taking a break and being able to focus, it really does. I can say it has helped with focus and is also calming my anxieties. I really need that. It's really a nice option. I recommend it. And the SERO team is really nice. They respond quickly 🙂
"Works! I've been looking for this blend ever since I heard Paul Stamet discussing it. When a man wears a mushroom cap like that you listen close 🙂 What a happy surprise when I found the blend sold by Sero. CONNECT FOUR has quality ingredients. Well formulated, and with no shortcuts or junk added. I've been taking it for months now and feel renewed. Can focus and remember better. From my experience, it is safe and effective. I trust this product and will recommend it.”
Zoltan K.
"I have just started the micro-dosing process. After the third week I definitely felt stronger and more energetic. I suffer from MS and fatigue, balance and lack of leg strength are daily issues. After micro-dosing for three weeks I could feel real change. The change was small but there was positive change without a doubt. Balance, strength and naps are less of a daily concern. Thanks for providing a product that is natural and works. Nice change to big pharma pushing their expensive ineffective MS solutions.
Mark C.
"This was my first time ever microdosing, so I decided to start with Connect Four 75 mg. I suffer from depression, social anxiety/GAD and I struggle with focusing. I tried antidepressants & felt they did nothing for me. I was desperate for something to work, and heard a lot of great things about microdosing. I felt like I had nothing to lose and was at my rock bottom. After 8 weeks of on and off microdosing - WOW. I haven't felt this good in about 8 years. My mood is up, my social anxiety is still there but it's definitely lessened ALOT. I have more energy & my focus is MUCH better that I feel I can actually have conversations with people. Over the past month and a half, I've also been exercising regularly, meditating, journaling & reading. The combination of all has really improved my quality of life. I have one more day of microdosing, then I'll be taking a 2-3 week break. I already have my cart filled for my next round 🙂 thanks HeySero for creating such an amazing product."
Taylor S.

Have any questions about microdosing, psilocybin, the Stamets Stack, or really anything under the mushroom-related sun? Send us a message anytime and we’re happy to help! You can direct your message to our Sero team, one of our partner Psychedelic Therapists, or an experienced psychonaut in our community.